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Autoregulation Assessment During Liver Transplantation

NCT01425385 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2017-08-22

No results posted yet for this study

Summary

Patients with liver failure undergoing liver transplantation often have clinical or sub-clinical encephalopathy that may lead to increased intracranial pressure. The latter may lead to abnormal regulation of blood flow to the brain (cerebral autoregulation) complicating patient management during and after general anesthesia. The current methods for monitoring for elevated intracranial pressure are invasive and, thus, limited to severe encephalopathy. In this study the investigators will evaluate the potential utility of monitoring cerebral blood flow (CBF) autoregulation non-invasively using near infra-red spectroscopy in patients undergoing liver transplantation.

Conditions

  • Liver Failure
  • Liver Transplantation
  • Encephalopathy

Interventions

OTHER

Near infrared spectroscopy monitoring

This is an observational study without interventions

OTHER

Autoregulation monitoring

There are no interventions in this observational study

Sponsors & Collaborators

Principal Investigators

  • Charles W Hogue, MD · Johns Hopkins University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2012-09-30
Completion
2012-09-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01425385 on ClinicalTrials.gov