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Evaluation of Propranolol's Effect on Pain and Inflammation.

NCT01094574 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2017-02-24

Study results available
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Summary

Previous studies have shown that the beta-adrenergic system plays a role in processing pain and the expression of hyperalgesia. Recent studies have investigated the analgesic effects, and potential anti-hyperalgesic effects (using a model of opioid induced (OIH) hyperalgesia) of propranolol, a beta adrenergic antagonist. We plan to further investigate the analgesic effects, and the potential anti inflammatory effects, of propranolol and compare those effects to alfentanil, an opioid of known effect, and placebo

Conditions

  • Pain Measurement

Interventions

DRUG

Alfentanil

An infusion of alfentanil 100ng/ml was administered over 3 hours using a programmable infusion pump.

DRUG

Propranolol

An infusion of propranolol 30ng/ml was administered over 3 hours using a programmable infusion pump.

DRUG

Placebo

An infusion of normal saline was administered over 3 hours using a programmable infusion pump to mimic the 2 drug arms,

Sponsors & Collaborators

  • Martin Angst

    lead OTHER

Principal Investigators

  • Martin S Angst · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2010-06-30
Completion
2010-08-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01094574 on ClinicalTrials.gov