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Hyperalgesia and Pain

NCT01581450 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-09-11

No results posted yet for this study

Summary

Evaluation of the effects of 35%/15%/50% N2O/N2/O2 mixtures on the area of hyperalgesia induced by remifentanil in the CCES (Continuous Cutaneous Electrical Stimulation) model in 20 healthy volunteers.

The duration of participation for each volunteer is expected to be around 9 weeks with the performance of 4 experimental session 2 weeks apart.

The selection visit will last half a day; each experimental session will last half a day; the study end will last 2 hours maximum.

Conditions

  • Hyperalgesia

Interventions

DRUG

Nitrous Oxide

35%

DRUG

Nitrous Oxide

50%

Sponsors & Collaborators

  • ORION Clinical Services

    collaborator INDUSTRY

  • Air Liquide Santé International

    lead INDUSTRY

Principal Investigators

  • Andreas WEHRFRITZ, MD · University of Erlangen-Nürnberg, Germany

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-01-31
Primary Completion
2012-04-30
Completion
2012-04-30

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01581450 on ClinicalTrials.gov