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Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

NCT03781544 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2024-05-17

No results posted yet for this study

Summary

Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy subjects.

Conditions

  • Osteoarthritis of Multiple Joints of Ankle or Foot
  • Healthy

Interventions

DRUG

Tramadol

A single i.v. infusion of Tramadol (dose: 400mg/100ml) will be administered to the participants (treatment arm).

DRUG

Paracetamol

A single i.v. infusion of Paracetamol (dose: 1g/100ml) will be administered to the participants (control arm).

DRUG

Diclofenac

A single i.v. infusion of Diclofenac (dose: 75mg/100ml) will be administered to the participants (treatment arm).

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Frank Ruschitzka, MD · Cardiology, University Heart Center Zurich

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2025-07-31
Completion
2025-12-31

Countries

  • Switzerland

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03781544 on ClinicalTrials.gov