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Brain Response to Pain Control in People With Chronic Pain

NCT01878019 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 92

Last updated 2019-12-09

No results posted yet for this study

Summary

Background:

\- Researchers want to look at how the brain responds to painful stimulations. They also want to see if these responses are different in people with and without chronic pain. To test the brain s response, they will use a chemical called naloxone. Naloxone is used to treat overdoses of painkilling drugs like morphine. It may be able to block the effect of a pain-relieving cream. Researchers will apply a pain-relieving cream to a person s lower leg and look at the results of sensitivity tests with either naloxone or a placebo. This study will compare the results from people with chronic pain (like fibromyalgia) to those of people without chronic pain.

Objectives:

\- To look at the brain s response to pain in people with and without chronic pain.

Eligibility:

* Individuals at least 18 years of age who have fibromyalgia.
* Healthy volunteers at least 18 years of age.

Design:

* This study will involve a screening visit and two testing visits. The testing visits will be about a week apart.
* Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. After the screening participants will be administered several questionnaires about their personality, and their thoughts and feelings.
* At the first visit, participants will try out the magnetic resonance imaging (MRI) scan before using it at the next visit. They will then have the painkilling cream applied on one part of their lower leg and a normal moisturizing cream on the other part of their lower leg. They will have heat pulses on these skin areas and rate the pain.
* At the second visit, participants will have tests in the MRI scanner. The heat pulse tests will be repeated after an infusion of either naloxone or a placebo.

Conditions

Sponsors & Collaborators

  • National Center for Complementary and Integrative Health (NCCIH)

    lead NIH

Principal Investigators

  • Mary C Bushnell, Ph.D. · National Center for Complementary and Integrative Health (NCCIH)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-05-28
Primary Completion
2016-09-08
Completion
2016-09-08

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01878019 on ClinicalTrials.gov