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Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol

NCT01000337 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 67

Last updated 2017-05-19

Study results available
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Summary

Anesthesia may affect the function of vital organs. Liver is one of them. The investigator's hypothesis is that intravenous or inhalation anesthesia does not impair liver function as assessed by more elegant tests like markers indicating liver apoptosis. In the present randomized prospective trial female patients scheduled for mastectomy or thyroidectomy will receive inhalation or total intravenous anesthesia and markers for liver dysfunction will be determined.

Conditions

  • Liver Dysfunction

Interventions

DRUG

Sevoflurane

Sevoflurane concentration for induction of anesthesia 7-8%, for maintenance of anesthesia 2%.

DRUG

Propofol

Propofol to induce anesthesia 2.5 mg/kg, for maintenance of anesthesia 6 mg/kg/h

Sponsors & Collaborators

  • University of Athens

    lead OTHER

Principal Investigators

  • Argyro Fassoulaki, MD,PhD,DEAA · Chairman Department of Anesthesiology, Aretaieio Hospital

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2011-11-30
Completion
2012-04-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01000337 on ClinicalTrials.gov