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Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults

NCT05693428 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2023-01-23

No results posted yet for this study

Summary

Abstract Cardiac surgery in adults is associated with the occurrence of post-operative complications. Even minor complications can increase the cost of their treatment. Given the potentially preventable nature of a number of these postoperative complications, preventive methods should be used to improve outcomes after cardiac surgery. One of them, is the choice of anaesthetic technique.

Objectives: To evaluate the effects of sevoflurane, isoflurane and propofol on blood oxygen transport function and body energy expenditure during cardiac surgery in adults.

Materials and methods. A total of 90 patients were included in the study. All patients were divided into 3 groups: 1- (n=30) included patients who were anesthetized with propofol. The second group (n=30) consisted of patients who underwent sevoflurane inhalation anaesthesia. Group 3 (n=30) was treated with isoflurane. All patients underwent coronary artery bypass grafting under cardiopulmonary bypass.

Conditions

  • CHD - Coronary Heart Disease

Interventions

DRUG

Propofol

To maintain anaesthesia in Group 1 P, propofol was used as an anaesthetic in a dose of 5-6 mg/kg/h intravenously on a perfusor.

DRUG

Isoflurane

isoflurane was used as anaesthetice of - 1.1-1.2 MAC.

DRUG

Sevoflurane

sevoflurane was used as an anaesthetic in a dose of - 1.7-1.9 MAC

Sponsors & Collaborators

  • Astana Medical University

    lead OTHER

Principal Investigators

  • Alibek Kh Mustafin, Professor · Astana Medical University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
SEQUENTIAL

Eligibility

Min Age
45 Years
Max Age
67 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-22
Primary Completion
2022-11-19
Completion
2022-11-26

Countries

  • Kazakhstan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05693428 on ClinicalTrials.gov