Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia

Summary

The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.

Conditions

• Breast Neoplasms
• Colonic Neoplasms
• Rectal Neoplasms

Interventions

DRUG

Propofol

Propofol will be infused individually for a sufficient level of anesthesia during the entire surgical procedure.

DRUG

Sevoflurane

Sevoflurane will be administered by vaporizer individually for a sufficient level of anesthesia during the entire surgical procedure.

Sponsors & Collaborators

• Region Örebro County

  collaborator OTHER

• University Hospital, Linkoeping

  collaborator OTHER

• Lund University Hospital

  collaborator OTHER

• Kalmar County Hospital

  collaborator OTHER

• Skellefteå lasarett

  collaborator UNKNOWN

• Wroclaw Medical University

  collaborator OTHER

• Sundsvall Hospital

  collaborator OTHER

• Peking University First Hospital

  collaborator OTHER

• Helsingborgs Hospital

  collaborator OTHER

• Air Force Military Medical University, China

  collaborator OTHER

• RenJi Hospital

  collaborator OTHER

• Uppsala University Hospital

  collaborator OTHER

• University Hospital Sestre Milosrdnice

  collaborator OTHER

• Växjö Hospital

  collaborator UNKNOWN

• Uppsala University

  lead OTHER

Principal Investigators

• Mats Enlund, M.D., Ph.D. · Uppsala university, Center of Clinical Research, Vasteras, Sweden

• Leif Bergkvist, M.D., Ph.D. · Uppsala university, Center of Clinical Research, Vasteras, Sweden

Study Design

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-11-30

Primary Completion

2022-08-31

Completion

2022-08-31

Countries

• China
• Poland
• Sweden

Study Locations