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CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

NCT00991679 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2009-10-08

No results posted yet for this study

Summary

The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.

Thirty-three patients with dry eye (16 Sjögren's syndrome and 17 non-Sjögren's syndrome patients) and 15 control subjects were recruited. The concentrations of CXCL9, CXCL10, and CXCL11 in tears were measured using enzyme-linked immunosorbent assay. The correlation between chemokine levels and tear film and ocular surface parameters was analyzed. Expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the conjunctiva was evaluated using immunohistochemistry. Flow cytometry was performed to count CXCR3+ cells and CXCR3+CD4+ cells in the conjunctiva.

Conditions

  • Dry Eye Syndrome

Sponsors & Collaborators

  • Chonnam National University Hospital

    lead OTHER

Principal Investigators

  • Kyung-Chul Yoon, MD, PhD · Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea

Eligibility

Min Age
24 Years
Max Age
77 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-02-29
Primary Completion
2008-10-31
Completion
2008-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00991679 on ClinicalTrials.gov