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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

NCT00985049 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2024-08-22

No results posted yet for this study

Summary

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Conditions

Sponsors & Collaborators

  • American Heart Association

    collaborator OTHER

  • Harvard Medical School (HMS and HSDM)

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Jochen D. Muehlschlegel, MD, MMSc, MBA · Johns Hopkins University

  • Sergey Karamnov, MD · Brigham and Women's Hospital

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-03-31
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00985049 on ClinicalTrials.gov