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Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement

NCT01804283 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2013-03-05

No results posted yet for this study

Summary

1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral).
2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.
3. Downstream effectors would also be affected.

Conditions

  • Cardiopulmonary Bypass
  • Ischemic Postconditioning

Interventions

PROCEDURE

ischemic postconditioning

multiple brief ischemic-reperfusion episodes immediately after sustained ischemic insult Postconditioning was started at 30 s after aortic cross declamping, and the aorta was re-clamped for 30 s rendering global myocardial ischemia. Meanwhile aortic root suction was established during aortic re-clamping, and thereafter, the aortic clamp was released for 30 s for full myocardial reperfusion. The cycle was repeated three times after cardioplegic arrest.

PROCEDURE

double valve replacement

The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves.

DEVICE

heart-lung machine

The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation.

DEVICE

Aortic cross-clamp

a surgical instrument used in cardiac surgery to clamp the aorta

Sponsors & Collaborators

  • Central South University

    lead OTHER

Principal Investigators

  • Wanjun Luo, MD · Xiangya Hospital of Central South University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-03-31
Primary Completion
2013-03-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01804283 on ClinicalTrials.gov