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Effects of Methylprednisolone After Total Knee Arthroplasty

NCT00968578 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2012-09-26

No results posted yet for this study

Summary

The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after knee arthroplasty.

The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce pain and improve outcome.

Conditions

  • Postoperative Pain
  • Postoperative Nausea and Vomiting
  • Sleeping Quality
  • Fatigue
  • Inflammatory Response

Interventions

DRUG

Methylprednisolone

Methylprednisolone 125 mg iv pre-operatively

DRUG

Placebo

Saline iv pre-operatively in equivalent volume (placebo)

Sponsors & Collaborators

  • Lundbeck Foundation

    collaborator OTHER

  • Hvidovre University Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-08-31
Primary Completion
2009-12-31
Completion
2009-12-31

Countries

  • Denmark

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00968578 on ClinicalTrials.gov