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A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation

NCT04432012 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 159

Last updated 2025-08-06

No results posted yet for this study

Summary

We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.

Conditions

  • Total Knee Replacement

Interventions

DRUG

Dexamethasone Sodium Phosphate 4 mg/ml intravenous

Perioperative intravenous injection of 3 ml of solution (9mg of dexamethasone)

DRUG

Dexamethasone Sodium Phosphate 4 mg/ml intra-articular

Perioperative intra-articular injection of 3 ml of solution (9mg of dexamethasone)

Sponsors & Collaborators

  • Christian Candrian

    lead OTHER

Principal Investigators

  • Christian Candrian, MD, Prof. · EOC

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-07-01
Primary Completion
2026-04-30
Completion
2033-04-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04432012 on ClinicalTrials.gov