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Methadone Versus Morphine for Orthopedic Surgery Patients

NCT00892606 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2017-06-14

Study results available
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Summary

The investigators propose to compare analgesia by methadone and ketamine with a combination of morphine and ketamine in orthopedic surgery patients with moderate to severe pain. The investigators hypothesize that when given with ketamine before surgical incision, methadone is more effective than morphine in reducing postoperative morphine consumption and reducing pain during movement.

Conditions

  • Fracture
  • Pain, Postoperative

Interventions

DRUG

Methadone

Patients will receive 0.2 mg/kg of methadone IV immediately after intubation

DRUG

Morphine

Patients will receive 0.2 mg/kg of morphine IV immediately after intubation

Sponsors & Collaborators

  • University of Louisville

    lead OTHER

Principal Investigators

  • Anupama Wadhwa, MD · University of Louisville

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-01-31
Primary Completion
2013-12-31
Completion
2013-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00892606 on ClinicalTrials.gov