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Oral Methadone in Cardiac Surgery

NCT07221617 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-01-14

No results posted yet for this study

Summary

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

Conditions

  • Pain, Postoperative
  • Anesthesia
  • Cardiac Surgery

Interventions

DRUG

Methadone, oral

Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room

DRUG

Methadone, intravenously

Patients will receive 0.3mg/kg methadone intravenously after induction of general anesthesia

Sponsors & Collaborators

Principal Investigators

  • Krishnan Ramanujan, M.D. · Mayo Clinic

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-13
Primary Completion
2026-06-30
Completion
2026-08-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07221617 on ClinicalTrials.gov