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Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries

NCT00835965 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2009-02-04

No results posted yet for this study

Summary

The combination of aprepitant and lower dose dexamethasone is superior to aprepitant alone with respect to the proportion of patients with a complete response (no vomiting and no use of rescue therapy) during 24 hours after the placement of last suture/staple.

Conditions

Interventions

DRUG

Dexamethasone

Dexamethasone 5 mg administered intravenously following endotracheal intubation

DRUG

Aprepitant

Aprepitant 40mg PO one time at least one hour prior to induction of anesthesia

DRUG

Placebo Dexamethasone

Sponsors & Collaborators

  • Merck Sharp & Dohme LLC

    collaborator INDUSTRY

  • Drexel University College of Medicine

    collaborator OTHER

  • Main Line Health

    lead OTHER

Principal Investigators

  • Dmitri Chamchad, MD · Lankenau Hospital, Lankenau Institute for Medical Research

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-02-28
Primary Completion
2009-12-31

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00835965 on ClinicalTrials.gov