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Identification of Novel Targets for Regulation of Adipose Tissue Mass

NCT00773565 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2012-08-23

No results posted yet for this study

Summary

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Conditions

Interventions

DIETARY_SUPPLEMENT

Optifast

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Sponsors & Collaborators

  • Swiss Federal Institute of Technology

    collaborator OTHER

  • Gottfried Rudofsky

    lead OTHER

Principal Investigators

  • Christian Wolfrum, PhD · ETH Zürich

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2011-08-31
Completion
2011-08-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00773565 on ClinicalTrials.gov