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The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women

NCT07315282 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2026-01-02

No results posted yet for this study

Summary

The study will be a randomized, double-blind, 17-day metabolic intervention trial including 14 days of high-dose or low-dose iron supplementation. A total of 70 overweight or obese (OW/OB) women will be enrolled. Participants will be individually randomized into either the high-iron or low-iron group.

Women in the low-iron group will receive 15 mg of iron as ferrous fumarate daily for 14 days, while women in the high-iron group will receive 195 mg of iron as ferrous sulfate daily for 14 days.

The study consists of three visits in total. On Day 0, a fasting blood sample will be collected and an OGTT will be performed, with additional blood samples collected at 1 hour and 2 hours post-OGTT. The OGTT will be repeated on Day 14, after 14 days of oral iron supplementation, and again on Day 17, four days after oral iron supplementation has been stopped

Conditions

  • Overweight and Obese Women

Interventions

DIETARY_SUPPLEMENT

195 mg iron daily

3 x 65 mg iron as ferrous sulfate

DIETARY_SUPPLEMENT

15 mg iron daily

3 x 5 mg iron as ferrous sulfate

Sponsors & Collaborators

  • American University of Beirut Medical Center

    collaborator OTHER

  • Nicole Stoffel

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-23
Primary Completion
2026-06-30
Completion
2026-06-30

Countries

  • Lebanon

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07315282 on ClinicalTrials.gov