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A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement

NCT00756236 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2017-07-31

Study results available
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Summary

We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups. Our hypothesis is that the metoprolol and esmolol groups will require a lower level of anesthetic agent to achieve the targeted BIS range, compared to the placebo group.

Our objective is to clarify if metoprolol, in a dose range used for perioperative cardiac protection, decreases anesthetic requirement.

Conditions

  • Myocardial Ischemia

Interventions

DRUG

Metoprolol

60ml syringes of 0.9% NaCl, 5ml syringes of metoprolol at 1mg/ml concentration

DRUG

Esmolol

60ml syringes of esmolol at 10 mg/ml concentration, 5ml syringes of 0.9% of NaCl

DRUG

P-Group

0.9%NaCl dispensed in 60ml \& 5ml syringes

Sponsors & Collaborators

  • University of Oklahoma

    lead OTHER

Principal Investigators

  • Pramod Chetty, MD · Faculty, Anesthesiology

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2015-09-02
Completion
2015-09-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00756236 on ClinicalTrials.gov