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Effect of Esmolol on Perioperative Stress Reaction

NCT05694585 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 46

Last updated 2023-01-23

No results posted yet for this study

Summary

The goal of this clinical trial is to observe the effect of low dose continuous infusion of esmolol on perioperative stress response in patients undergoing airway intervention .

Conditions

  • Esmolol
  • Stress Reaction
  • Airway Obstruction
  • Catecholamine; Overproduction

Interventions

DRUG

Esmolol

Esmolol 50μg/kg /min is intravenously administered before Operation beginning. If HR（heart rate）is greater than 90 beats/min, esmolol 50μg/kg/min is added each time, with interval more than 5 min and the peak value is 200 μg/kg/min. If the heart rate is lower than 60 times/minute, Stop medication.

DRUG

saline

Saline 50μg/kg /min were iv administered before Operation beginning. If HR（heart rate）is greater than 90 beats/min, saline 50μg/kg/min is added each time, with interval more than 5 min and the peak value is 200 μg/kg/min. If the heart rate is lower than 60 times/minute, Stop medication.

Sponsors & Collaborators

  • Xiumei Song

    lead OTHER

Principal Investigators

  • Jinwan Guo, Master · Qianfoshan Hospital

  • Ling Dong, M.D. · Qianfoshan Hospital

  • Yang Liu, M.D. · Qianfoshan Hospital

  • Liang Guo, M.D. · Qianfoshan Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2023-12-31
Completion
2023-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05694585 on ClinicalTrials.gov