Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)
NCT00655993 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2023-04-26
Summary
Hypothesis for this pilot study is that simvastatin will lower the levels of CRP and ET-1 in COPD patients.
Conditions
Interventions
- DRUG
-
simvastatin
40 mg po daily
Sponsors & Collaborators
-
VA Loma Linda Health Care System
lead FED
Principal Investigators
-
Lennard Specht, M.D. · VA Loma Linda Health Care System
-
Hemal J. Parekh, M.D. · VA Loma LInda Healthcare System
-
James D. Anholm, M.D. · VA Loma Linda Healthcare System
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 40 Years
- Max Age
- 79 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2008-04-30
- Primary Completion
- 2009-03-31
- Completion
- 2014-08-31
Countries
- United States
Study Locations
More Related Trials
-
Muscle Characteristics Associated With Statin Therapy
NCT00990834 ·Status: WITHDRAWN ·Phase: NA
-
Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery
NCT00656292 ·Status: COMPLETED ·Phase: PHASE4
-
Pleiotropism of Statin Therapy in High Dose Versus Low Dose Combined With Ezetimibe
NCT01241097 ·Status: UNKNOWN ·Phase: NA
-
Colchicine and CRP in Atrial Fibrillation and AF Ablation
NCT01755949 ·Status: COMPLETED ·Phase: PHASE2
-
The Acute Effect of Statins on Inflammatory Markers of Athersclerotic Tissue
NCT00587717 ·Status: COMPLETED ·Phase: NA
-
High Dose and Low Dose of Atorvastatin in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)
NCT01306565 ·Status: COMPLETED ·Phase: NA
-
Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease
NCT02579499 ·Status: UNKNOWN ·Phase: PHASE4
-
Effects of Statins on Pro- and Antioxidant Status : Link With Statin-Associated Myopathy.
NCT00285181 ·Status: COMPLETED ·Phase: NA
-
Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis
NCT01106495 ·Status: COMPLETED ·Phase: NA
-
Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography
NCT06520904 ·Status: RECRUITING ·Phase: PHASE4
-
Statin Therapy in Heart Failure: Potential Mechanisms of Benefit
NCT00233480 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention
NCT00588471 ·Status: TERMINATED ·Phase: NA
-
Effect of Statins on Asthma Control in Smokers With Asthma
NCT00463827 ·Status: COMPLETED ·Phase: PHASE2
-
The Effect on EPCs by Statin Loading in "All Comers" With an ACS
NCT02957162 ·Status: COMPLETED ·Phase: PHASE4
-
BIOchemical Urine Analysis of Adherence to Statins and Associated FACTorS in Coronary Artery Disease
NCT05814692 ·Status: UNKNOWN
-
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
NCT00166036 ·Status: COMPLETED ·Phase: PHASE2
-
The Effect of Atorvastatin on Endothelial Cell Dysfunction in Chronic Kidney Disease
NCT02133534 ·Status: TERMINATED ·Phase: PHASE4
-
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model
NCT00309374 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Statins on Trained Immunity
NCT02817230 ·Status: COMPLETED
-
A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173)
NCT03882905 ·Status: COMPLETED ·Phase: PHASE3
-
Exercise, Statins, and the Metabolic Syndrome
NCT01700530 ·Status: COMPLETED ·Phase: NA
-
Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI
NCT01293097 ·Status: COMPLETED ·Phase: PHASE4
-
Statin Therapy to Improve Medication Adherence
NCT01894217 ·Status: COMPLETED ·Phase: PHASE1
-
The Role of Atorvastatin on Monocyte Function in Patients With Coronary Artery Disease and Hypercholesterolemia
NCT00329069 ·Status: COMPLETED ·Phase: NA
-
The Impact of Statin Therapy in the Covid-19 Patients
NCT05238402 ·Status: COMPLETED