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Exercise, Statins, and the Metabolic Syndrome

NCT01700530 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 121

Last updated 2016-02-05

Study results available
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Summary

Here we tested if statins or exercise plus statins had a greater capacity to lower metabolic syndrome risk factors in sedentary individuals with at least 2 metabolic syndrome risk factors. We also examined if statins impacted exercise response for mitochondrial content in muscle or aerobic fitness.

Conditions

  • Metabolic Syndrome
  • Obese
  • Sedentary

Interventions

DRUG

Statin

Statins (40mg/day)for 12 weeks

OTHER

Exercise only

12 weeks of exercise training (5 days a week for 45-50 min a session)

OTHER

Statins + Exercise

Statins (40mg/day of simvastatin) plus exercise training (5 days/wk for 45-50 min a session) for 12 weeks

Sponsors & Collaborators

  • University of Missouri-Columbia

    collaborator OTHER

  • American Heart Association

    collaborator OTHER

  • University of Kansas Medical Center

    lead OTHER

Principal Investigators

  • John P Thyfault, PhD · University of Missouri-Columbia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
59 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-05-31
Primary Completion
2011-05-31
Completion
2011-05-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01700530 on ClinicalTrials.gov