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Pleiotropism of Statin Therapy in High Dose Versus Low Dose Combined With Ezetimibe

NCT01241097 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2010-11-16

No results posted yet for this study

Summary

* To test the hypothesis that therapy with high dose statin provides endothelial superior benefit to the same cholesterol lowering with low-dose statin combined with ezetimibe.
* To test the hypothesis that therapy with high dose statin provides anti-inflammatory effect than the same reduction of cholesterol with low dose of statin plus ezetimibe

Conditions

  • Endothelial Function

Interventions

DRUG

simvastatin, combined with simvastatin ezetimibe, placebo

simvastatin 80 mg per days or simvastatin 10 mg and ezetimibe 10 mg, over a period of eight weeks, treatment consisted of tablets identical, or placebo

Sponsors & Collaborators

  • Escola Bahiana de Medicina e Saude Publica

    collaborator OTHER

  • Federal University of Bahia

    lead OTHER

Principal Investigators

  • Maristela M Garcia, MD · Escola Bahiana de Medicina e Saúde Pública

Study Design

Allocation
RANDOMIZED
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2010-12-31
Completion
2011-12-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01241097 on ClinicalTrials.gov