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Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity

NCT03351998 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2024-12-18

Study results available
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Summary

The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.

Conditions

  • Mitochondrial Diseases

Interventions

DRUG

Lipitor 20Mg Tablet

20 mg/day pills.

DRUG

Lipitor 80Mg Tablet

80 mg/day pills.

DRUG

Placebo Oral Tablet

Matching placebo pill.

Sponsors & Collaborators

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    collaborator NIH

  • University of Kansas Medical Center

    lead OTHER

Principal Investigators

  • John Thyfault, PhD · University of Kansas Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-22
Primary Completion
2023-07-07
Completion
2023-07-07
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03351998 on ClinicalTrials.gov