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Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

NCT00571272 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 1675

Last updated 2025-10-15

No results posted yet for this study

Summary

Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid synthesis and metabolism defects, and progressive familial intrahepatic cholestasis (PFIC) or benign recurrent intrahepatic cholestasis(BRIC). This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases.

Conditions

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Arbor Research Collaborative for Health

    lead OTHER

Principal Investigators

  • Kathleen Loomes, MD · Children's Hospital of Philadelphia

  • Ed Doo, MD · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • John Magee, MD · University of Michigan

  • Lisa Henn, PhD · Arbor Research Collaborative for Health

  • Katrina Loh, MD · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Eligibility

Max Age
25 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-11-30
Primary Completion
2029-05-31
Completion
2029-05-31

Countries

  • United States
  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00571272 on ClinicalTrials.gov