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Regulation of Sterol Homeostasis

NCT00018720 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2009-01-21

No results posted yet for this study

Summary

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

Conditions

  • Hypertriglyceridemia

Sponsors & Collaborators

Principal Investigators

  • Norman Javitt, M.D.

  • Alan Hofmann, M.D.

  • Loren Zech, M.D.

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1996-04-30
Completion
2000-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00018720 on ClinicalTrials.gov