Observational Study of Early Metabolic and Vascular Changes in Obesity

Summary

To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003. STYJOBS / EDECTA is a prospective, observational study to improve the understanding of atherosclerosis, cardiovascular risk, immune mediated low grade Inflammation, metabolic changes, and general disease propensity in obesity. The investigation of the "non-biased" early phase is strongly focused.

Based on this information, new and effective strategies for preclinical diagnostics and early intervention are of main interest. We seek a better understanding of critical lipid profiles, chronic immune-mediated inflammation, disturbed adipokine balance, critical adipose tissue topography, addiction like behaviour, genetics/epigenetics, early vascular pathology, and fatty liver disease. Interventional branches of study tested a holistic strategy comprehending sports, and lifestyle modification for efficiency. The investigative spectrum of STYJOBS / EDECTA comprehends also non-obese body weight extremes i.e. underweight/anorectic people.

Conditions

• Obesity
• Atherosclerosis
• Inflammation
• Adiponectin Deficiency
• Fatty Liver

Interventions

OTHER

Lifestyle intervention

Regular sports and dietary advices. Controlled by analysis of laboratory parameters, BMI change and performance diagnostics. No drugs included so far.

Sponsors & Collaborators

• Zukunftsfonds Steiermark

  collaborator OTHER

• Bundesministerium für Gesundheit, Familie und Jugend

  collaborator UNKNOWN

• Steiermärkische Landesregierung

  collaborator UNKNOWN

• Graz University of Technology

  collaborator OTHER

• University of Graz

  collaborator OTHER

• Paracelsus Medical University

  collaborator OTHER

• Technical University of Munich

  collaborator OTHER

• Medical University of Graz

  lead OTHER

Principal Investigators

• Harald Mangge, Prof., MD · Medical University of Graz, Austria

Eligibility

Min Age

3 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2003-01-31

Primary Completion

2022-12-31

Completion

2022-12-31

Countries

• Austria

Study Locations