Diet and Physical Activity on NAFLD and Erytrocyte Membrane Lipid Profile.

Summary

This study aims to evaluate the effect of two programs of different intensity level of physical activity, of low glycemic index Mediterranean Diet and of the interaction of both, on NAFLD score and on the lipid composition of the erythrocyte membrane.

Conditions

• NAFLD

Interventions

BEHAVIORAL

Control

Subjects will follow a diet based on INRAN guidelines without doing any physical activity.

BEHAVIORAL

LGIMD

Subjects will follow a Low Glycemic Index Mediterranean Diet (LGIMD) without doing any physical activity.

BEHAVIORAL

Endurance Activity (EA)

Subject will follow a program of endurance activity as follows: Frequency: 3 times/week Duration: 60 minutes Intensity: * weeks 1-4: 14.2 kcal\*kg-1\*week-1; * weeks 5-8: 18.9 kcal\*kg-1\*week-1; * weeks 9-12: 23.6 kcal\*kg-1\*week-1.

BEHAVIORAL

EA+Resistance Training (RT)

Subject will follow a program of endurance activity as follows: Frequency: 3 times/week Duration: 60 minutes Intensity (for Endurance activity): * weeks 1-4: 14.2 kcal\*kg-1\*week-1; * weeks 5-8: 18.9 kcal\*kg-1\*week-1; * weeks 9-12: 23.6 kcal\*kg-1\*week-1. Resistance activity: Muscolation: Training of the bigger muscle groups (chest, shoulders, arms, abdomen, back, glutes and legs); * Progression: increase of 1-2.5 kg\*week-1 * Training of all muscle groups in the same session

BEHAVIORAL

LGIMD+EA

Subjects will follow a Low Glycemic Index Mediterranean Diet together with a program of endurance activity.

BEHAVIORAL

LGIMD+EA/RT

Subjects will follow a Low Glycemic Index Mediterranean Diet together with a program of both endurance activity and resistance training.

Sponsors & Collaborators

• Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

  lead OTHER

Principal Investigators

• Alberto R Osella, MD, PhD · IRCCS "Saverio De Bellis"

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-03-31

Primary Completion

2016-12-31

Completion

2016-12-31

Countries

• Italy

Study Locations