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Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD

NCT00281203 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2013-07-16

No results posted yet for this study

Summary

This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to bacterial and viral products. Specifically, the study will determine the dose-response characteristics of AMø for production of interleukin (IL)-6, IL-18, and IL-23 (pro-inflammatory cytokines) on stimulation by purified lipopolysaccharide, a synthetic lipopeptide (PAM3-Cys), or poly I:C. These stimuli mimic the response to Gram-negative bacteria, Gram-positive bacteria, and RNA viruses, respectively. Results of the AMø from these healthy volunteers will be compared with AMø of COPD patients and smokers (or ex-smokers) with normal pulmonary function; those samples are being obtained during clinically indicated bronchoscopies under a separate consent form.

Conditions

  • Pulmonary Disease, Chronic Obstructive
  • Lung Diseases, Obstructive

Interventions

PROCEDURE

blood drawing

blood will be drawn on the entry visit and will starting the intravenous (IV) line on the day of bronchoscopy

PROCEDURE

fiberoptic bronchoscopy

A flexible instrument will be passed through the mouth and into the lungs. Portions of the lungs will be washed, by injecting and immediately suctioning out a small amount of fluid. The entire return will be used for research purposes, and no results will be reported to the participant. Bronchoscopy is performed once.

Sponsors & Collaborators

Principal Investigators

  • Jeffrey L. Curtis · University of Michigan at Ann Arbor

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-09-30
Primary Completion
2010-07-31
Completion
2010-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00281203 on ClinicalTrials.gov