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Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function

NCT00281190 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2014-12-16

No results posted yet for this study

Summary

The purpose of this study is to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD ) show abnormal responsiveness to bacterial and viral products, relative to smokers with normal pulmonary function. Participation in this study will be offered to patients already scheduled to undergo a bronchoscopy for clinical indications.

Conditions

  • Pulmonary Disease, Chronic Obstructive
  • Lung Diseases, Obstructive

Interventions

PROCEDURE

Blood drawing

blood will be drawn at the time of starting the intravenous (IV) line for the procedure.

PROCEDURE

Bronchoalveolar lavage during indicated bronchoscopy

A small amount of liquid will be introduced and immediately sucked back out of portions of the lung, and the cells that are recovered will be analyzed in the laboratory. All test will be solely for research, and there will be no results reported to the subject from that fluid.

Sponsors & Collaborators

Principal Investigators

  • Jeffrey L. Curtis · University of Michigan at Ann Arbor

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-09-30
Primary Completion
2014-10-31
Completion
2014-10-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00281190 on ClinicalTrials.gov