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Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia

NCT00437060 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 233

Last updated 2017-07-21

No results posted yet for this study

Summary

This clinical trial is looking at brain function in young patients receiving methotrexate for acute lymphoblastic leukemia. Learning about the long-term effects of methotrexate on brain function may help doctors plan cancer treatment.

Conditions

  • Childhood B Acute Lymphoblastic Leukemia
  • Childhood T Acute Lymphoblastic Leukemia
  • Cognitive Side Effects of Cancer Therapy
  • Long-Term Effects Secondary to Cancer Therapy in Children
  • Neurotoxicity Syndrome
  • Psychological Impact of Cancer
  • Untreated Childhood Acute Lymphoblastic Leukemia

Interventions

PROCEDURE

Cognitive Assessment

Ancillary studies

PROCEDURE

Diffusion Tensor Imaging

Correlative studies

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Pharmacological Study

Correlative studies

PROCEDURE

Psychosocial Assessment and Care

Ancillary studies

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Children's Oncology Group

    lead NETWORK

Principal Investigators

  • Naomi Winick · Children's Oncology Group

Eligibility

Min Age
1 Year
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-01-31
Primary Completion
2015-09-30

Countries

  • United States
  • Australia
  • Canada
  • New Zealand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00437060 on ClinicalTrials.gov