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Effect of Folate on Colon and Blood Cells

NCT00220012 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2013-11-15

No results posted yet for this study

Summary

This study looks at the effect of folate supplementation and depletion on the blood cells and the colorectal cells. To examine the effect of these changes, blood samples and colorectal biopsy samples are collected. The genetic material (RNA and DNA) is examined to see what changes occur during the depletion and supplementation of folate. The hypothesis is that folate may help prevent colon cancer

Conditions

  • Subjects Will Have a Pre-cancerous Colorectal Polyp
  • Family Member Has History of Colorectal Adenoma of Adenocarcinoma

Interventions

PROCEDURE

Folate depletion and supplementation

Sponsors & Collaborators

  • Rockefeller University

    lead OTHER

Principal Investigators

  • Peter Holt, MD · Rockefeller University and Strang Cancer Institute

Study Design

Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
40 Years
Max Age
72 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-06-30
Completion
2008-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00220012 on ClinicalTrials.gov