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Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR

NCT01105351 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2018-05-14

No results posted yet for this study

Summary

The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.

Conditions

  • the Effect of MTHFR C677T on Folate Metabolism

Interventions

DIETARY_SUPPLEMENT

folic acid plus B6 and B12

folic acid 400 µg plus vitamin B12 plus B6

DIETARY_SUPPLEMENT

folic acid

folic acid 400 µg

Sponsors & Collaborators

  • Universität des Saarlandes

    lead OTHER

Principal Investigators

  • Rima Obeid, PhD · Department of Clinical Chemistry, University of Saarland

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-06-30
Primary Completion
2012-12-31
Completion
2013-12-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01105351 on ClinicalTrials.gov