Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy before surgery may shrink the tumor so it can be removed during surgery. Giving more chemotherapy after surgery may kill any remaining tumor cells. It is not yet known which chemotherapy regimen after surgery is most effective in treating Wilm's tumor.

PURPOSE: Phase III trial to study the effectiveness of chemotherapy before and after surgery in treating children who have Wilm's tumor.

Conditions

• Kidney Cancer

Interventions

BIOLOGICAL

dactinomycin

DRUG

carboplatin

DRUG

cyclophosphamide

DRUG

doxorubicin hydrochloride

DRUG

etoposide

DRUG

vincristine sulfate

PROCEDURE

adjuvant therapy

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

RADIATION

radiation therapy

Sponsors & Collaborators

• Societe Francaise Oncologie Pediatrique

  collaborator OTHER

• Children's Cancer and Leukaemia Group

  collaborator OTHER

• German Society for Pediatric Oncology and Hematology GPOH gGmbH

  collaborator OTHER

• University of Leicester

  lead OTHER

Principal Investigators

• Jan DeKraker, MD · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

• Francois Pein, MD · Gustave Roussy, Cancer Campus, Grand Paris

• Kathy Pritchard-Jones, MD · Royal Marsden NHS Foundation Trust

• Norbert Graf · Universitaetsklinikum des Saarlandes

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Eligibility

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2001-01-31

Countries

• France
• Germany
• Netherlands
• United Kingdom

Study Locations