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Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma

NCT00002898 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2013-12-04

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug with surgery and/or radiation therapy may kill more tumor cells.

PURPOSE: This randomized phase III trial is studying surgery followed by different regimens of combination chemotherapy given together with radiation therapy and/or additional surgery to compare how well they work in treating patients with soft tissue sarcoma.

Conditions

  • Childhood Malignant Fibrous Histiocytoma of Bone
  • Sarcoma

Interventions

BIOLOGICAL

dactinomycin

DRUG

carboplatin

DRUG

cyclophosphamide

DRUG

epirubicin hydrochloride

DRUG

etoposide

DRUG

ifosfamide

DRUG

vincristine sulfate

PROCEDURE

adjuvant therapy

PROCEDURE

conventional surgery

PROCEDURE

neoadjuvant therapy

RADIATION

brachytherapy

RADIATION

radiation therapy

Sponsors & Collaborators

  • Societe Internationale d'Oncologie Pediatrique

    lead OTHER

Principal Investigators

  • M. C. G. Stevens, MD · Institute of Child Health at University of Bristol

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT

Eligibility

Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1995-01-31
Completion
2009-12-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00002898 on ClinicalTrials.gov