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Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

NCT00000542 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL

Last updated 2016-07-29

No results posted yet for this study

Summary

To determine if the combined incidence of nonfatal myocardial infarction and coronary heart disease death differs between diuretic-based and each of three alternative antihypertensive pharmacological treatments. Also, to determine, in a subset of this population, if lowering serum cholesterol with a HMG CoA reductase inhibitor in older adults reduces all-cause mortality compared to a control group receiving usual care. Conducted in conjunction with the Department of Veterans' Affairs.

Conditions

Interventions

DRUG

Inhibitors, ACE

DRUG

amlodipine

DRUG

lisinopril

DRUG

doxazosin

DRUG

chlorthalidone

DRUG

pravastatin

BEHAVIORAL

diet, fat-restricted

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    lead NIH

Principal Investigators

  • Barry Davis · University of Texas

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION

Eligibility

Min Age
55 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1993-08-31
Primary Completion
2002-03-31
Completion
2002-03-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000542 on ClinicalTrials.gov