Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)

Summary

To determine whether reduction of cholesterol by drug therapy significantly lowered the atherosclerotic coronary heart disease rate in a group of hypercholesterolemic but otherwise healthy men.

Total dollars spent on the CPPT from June 1973 were $142,250,000. We do not have a year-by-year breakdown.

Conditions

• Cardiovascular Diseases
• Coronary Disease
• Heart Diseases
• Myocardial Ischemia

Interventions

DRUG

cholestyramine

BEHAVIORAL

diet, fat-restricted

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• Francois Abboud · University of Iowa

• Elizabeth Barrett-Connor · University of California, San Diego

• Reagan Bradford · Oklahoma Medical Research Foundation

• Marilyn Buzzard · University of Minnesota

• Gerald Cooper · Centers for Disease Control and Prevention

• John Farquhar · Stanford University

• Ivan Frantz · University of Minnesota

• Anne Goldberg · Washington University School of Medicine

• Frank Ibbott · Bio-Science Laboratories

• William, Insull · Baylor College of Medicine

• Robert Knoop · University of Washington

• Peter Kwiterovich · Johns Hopkins University

• John LaRosa · George Washington University

• J. Little · University of Toronto

• L. Sheffield · University of Alabama at Birmingham

• Dennis Sprecher · University of Cincinnati

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Eligibility

Min Age

35 Years

Max Age

59 Years

Sex

MALE

Healthy Volunteers

No

Timeline & Regulatory

Start

1973-06-30

Completion

1989-10-31