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Impact of Statin Therapy on Adaptations to Aerobic Exercise

NCT03360916 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2025-04-15

Study results available
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Summary

The purpose of this study is to determine how different doses of a statin affect muscle health and exercise.

Conditions

Interventions

DRUG

Lipitor 20Mg Tablet

One tablet by mouth every day for 12 weeks.

DRUG

Lipitor 80Mg Tablet

One tablet by mouth every day for 12 weeks.

DRUG

Placebo

One matching placebo tablet by mouth every day for 12 weeks.

BEHAVIORAL

Exercise Program

Exercise program of brisk walking and/or slow jogging on a treadmill for 90 minutes of exercise spread over 3 days during week 1, 150 minutes of exercise spread over 5 days during week 2, 225 minutes of exercise over 5 days during week 3 and for the rest of the study.

Sponsors & Collaborators

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    collaborator NIH

  • University of Kansas Medical Center

    lead OTHER

Principal Investigators

  • John Thyfault, PhD · University of Kansas Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-02-01
Primary Completion
2024-06-05
Completion
2024-06-05
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03360916 on ClinicalTrials.gov