Clinical Trials

NCT04743791 | RECRUITING | PHASE4

30 participants

Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-10-17
Completion:: 2027-12-31

Conditions

Asthma

Interventions

DRUG
OTHER

No Results Yet

NCT04730869 | COMPLETED | NA

18 participants

Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-05-26
Completion:: 2025-02-18

Conditions

Glioblastoma

Interventions

OTHER

No Results Yet

NCT04717349 | RECRUITING

11000 participants

Data Collection Study of Pediatric and Adolescent Gynecology Conditions

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-04-21
Completion:: 2039-12-02

Conditions

Disorders of Sex Development (DSD)
Pediatric and Adolescent Cancers of the Genital Tract
Reproductive Endocrine Conditions in Puberty
Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions

No Results Yet

NCT04715191 | RECRUITING | PHASE1

24 participants

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2024-05-24
Completion:: 2027-08-01

Conditions

Liver Cancer
Rhabdomyosarcoma
Malignant Rhabdoid Tumor
Liposarcoma
Wilms Tumor
Yolk Sac Tumor

Interventions

GENETIC

No Results Yet

NCT04640142 | ACTIVE_NOT_RECRUITING | PHASE3

50 participants

Study to Evaluate the Pharmacokinetics, Efficacy, Tolerability, and Safety of Subcutaneous Human Immunoglobulin (Newnorm) in Patients With Primary Immunodeficiency Diseases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-08-04
Completion:: 2026-09-30

Conditions

Primary Immune Deficiency

Interventions

BIOLOGICAL

No Results Yet

NCT04628026 | RECRUITING | PHASE3

650 participants

Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-09-13
Completion:: 2029-03-31

Conditions

Acute Myeloid Leukemia

Interventions

DRUG
COMBINATION_PRODUCT
OTHER

No Results Yet

NCT04599504 | COMPLETED | PHASE2/PHASE3

16 participants

Pharmacological and Behavioral Treatment After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2022-01-02
Completion:: 2026-06-04

Conditions

Loss-of-control Eating
Obesity/Overweight

Interventions

DRUG
OTHER

Results Available

NCT04527549 | TERMINATED | PHASE2

5 participants

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-06-01
Completion:: 2024-01-08

Conditions

Clinical Stage IV Cutaneous Melanoma AJCC v8
Locally Advanced Melanoma
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IV Cutaneous Melanoma AJCC v8
Unresectable Melanoma

Interventions

DRUG

Results Available

NCT04469959 | COMPLETED | PHASE2

79 participants

Dopaminergic Dysfunction in Late-Life Depression

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-02-15
Completion:: 2026-04-29

Conditions

Late Life Depression
Cognitive Decline
Depressive Disorder, Treatment-Resistant
Levodopa
Gait Impairment

Interventions

DRUG

No Results Yet

NCT04469686 | COMPLETED | PHASE3

200 participants

Phase 3 Study to Evaluate the Safety and Efficacy of Hydrocortisone Acetate Suppositories

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-12-10
Completion:: 2024-09-19

Conditions

Ulcerative Proctitis

Interventions

COMBINATION_PRODUCT

Results Available

NCT04455048 | COMPLETED | NA

84 participants

The Effectiveness of Manipulation Treatment in Cervical Region

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-02-02
Completion:: 2023-10-16

Conditions

Neck Pain

Interventions

OTHER

No Results Yet

NCT04450459 | COMPLETED

121 participants

Impact of Spiroergometer Parameters as Diagnostic Marker of Cardiac Ischemia in Pts. With Stable Angina Compared to FFR.

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-01-02
Completion:: 2025-08-25

Conditions

Stable Angina

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04386967 | COMPLETED | PHASE1/PHASE2

44 participants

OH2 Injection in Solid Tumors

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2018-11-22
Completion:: 2026-06-02

Conditions

Solid Tumor
Melanoma

Interventions

BIOLOGICAL
DRUG

No Results Yet

NCT04352569 | COMPLETED | NA

25 participants

Efficacy of tDCS in the Treatment of Resistant Auditory Hallucinations in Schizophrenia

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2016-05-03
Completion:: 2025-03-31

Conditions

Schizophrenia
Hallucinations
Refractory Schizophrenia

Interventions

DEVICE

No Results Yet

NCT04332341 | RECRUITING | EARLY_PHASE1

20 participants

Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-05-19
Completion:: 2026-09-30

Conditions

Allogeneic Hematopoietic Cell Transplantation

Interventions

DRUG

No Results Yet

NCT04298723 | RECRUITING | NA

530 participants

Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-06-16
Completion:: 2029-06-30

Conditions

Intracranial Hemorrhages
Atrial Fibrillation (AF)
Atrial Flutter

Interventions

DEVICE

No Results Yet

NCT04289324 | COMPLETED | NA

36 participants

Open Lung Maneuvers During High Frequency Oscillatory Ventilation in Preterm Infants

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-02-25
Completion:: 2025-08-31

Conditions

High Frequency Oscillation Ventilation
Extreme Prematurity
Lung Injury, Acute

Interventions

PROCEDURE

No Results Yet

NCT04246788 | COMPLETED | NA

40 participants

Intensive Robotic Rehabilitation in Children With Hemiparesia Using GEOSYSTEM

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-07-17
Completion:: 2021-11-24

Conditions

Infantile Hemiplegia

Interventions

OTHER

No Results Yet

NCT04224987 | COMPLETED | PHASE4

864493 participants

Azithromycin for Child Survival in Niger: Mortality and Resistance Trial

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-11-24
Completion:: 2024-07-31

Conditions

Mortality
Resistance Bacterial
Child, Only

Interventions

DRUG
OTHER

Results Available

NCT04221542 | RECRUITING | PHASE1

479 participants

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-03-04
Completion:: 2030-03-22

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT04221438 | TERMINATED | PHASE2

3 participants

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-09-22
Completion:: 2024-06-10

Conditions

Melanoma of Unknown Primary
Metastatic Malignant Neoplasm in Lymph Node
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Recurrent Cutaneous Melanoma

Interventions

DRUG
PROCEDURE
OTHER

Results Available

NCT04218617 | RECRUITING | PHASE2

130 participants

Single- vs. Two-Fraction Spine Stereotactic Radiosurgery for the Treatment of Vertebral Metastases

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-02-07
Completion:: 2026-10-31

Conditions

Spine Metastases
Spine Stereotactic Radiosurgery (sSRS)

Interventions

DEVICE
OTHER
RADIATION

No Results Yet

NCT04193878 | TERMINATED | PHASE3

465 participants

ARrest RESpiraTory Failure From PNEUMONIA

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-06-01
Completion:: 2025-07-22

Conditions

Pneumonia
Hypoxemia
Acute Respiratory Failure
COVID-19 Pneumonia

Interventions

DRUG

Results Available

NCT04192591 | ACTIVE_NOT_RECRUITING | NA

166 participants

A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-01-30
Completion:: 2038-02-28

Conditions

Lumbar Spinal Stenosis

Interventions

DEVICE

No Results Yet

NCT04179643 | COMPLETED | PHASE1

11 participants

AB-1002 in Patients With Class III Heart Failure

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-11-20
Completion:: 2024-08-20

Conditions

Congestive Heart Failure
Heart Failure
Heart Disease, Ischemic
Cardiovascular Diseases
Heart Failure, Systolic
Heart Failure，Congestive
Heart Arrhythmia
Heart Failure, Diastolic
Heart; Complications

Interventions

BIOLOGICAL

No Results Yet

NCT04165694 | COMPLETED | NA

54 participants

Single Anastomosis Duodenal Ileal Bypass (SADI) for Sleeve Revision

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-10-15
Completion:: 2025-05-01

Conditions

Bariatric Surgery Candidate
Severe Obesity

Interventions

PROCEDURE

No Results Yet

NCT04151940 | RECRUITING | NA

80 participants

PET/CT Changes During Chemoimmunotherapy and Radiation Therapy in Patients With Stage IV Non-small Cell Lung Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-09-26
Completion:: 2027-11-30

Conditions

Metastatic Lung Non-Small Cell Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8

Interventions

PROCEDURE
DRUG
BIOLOGICAL
RADIATION

No Results Yet

NCT04150939 | ACTIVE_NOT_RECRUITING | NA

15 participants

Cryoablation for the Treatment of Metastatic Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-12-23
Completion:: 2028-08-31

Conditions

Metastatic Malignant Neoplasm

Interventions

PROCEDURE
DRUG

No Results Yet

NCT04122976 | ACTIVE_NOT_RECRUITING

805 participants

A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-01-30
Completion:: 2026-07-20

Conditions

Prostate Cancer

Interventions

DRUG

No Results Yet

NCT04114903 | COMPLETED

233 participants

Exploring the Anti-inflammatory Properties of Cannabis and Their Relevance to Insulin Sensitivity

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-11-08
Completion:: 2024-12-01

Conditions

Type 2 Diabetes
Obesity
Cannabis Use
Insulin Sensitivity

Interventions

OTHER

Results Available

NCT04106713 | RECRUITING | NA

250 participants

Understanding the Person, Exploring Change Across Psychotherapies

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-10-04
Completion:: 2026-09-30

Conditions

Depression
Anxiety Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT04104139 | COMPLETED | PHASE1

19 participants

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-12-11
Completion:: 2024-09-25

Conditions

Rectal Adenocarcinoma
Stage IIA Rectal Cancer AJCC v8
Stage IIB Rectal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8
Stage IIIA Rectal Cancer AJCC v8
Stage IIIB Rectal Cancer AJCC v8
Stage IIIC Rectal Cancer AJCC v8

Interventions

RADIATION
DRUG

No Results Yet

NCT04098874 | COMPLETED | PHASE4

161 participants

Bupropion for the Prevention of Postpartum Smoking Relapse

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-01-01
Completion:: 2026-07-31

Conditions

Postpartum Smoking Relapse

Interventions

DRUG

No Results Yet

NCT04092010 | ACTIVE_NOT_RECRUITING | NA

388 participants

Improving Preschool Outcomes by Addressing Maternal Depression in Head Start

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2023-08-16
Completion:: 2028-04-30

Conditions

Maternal Depression

Interventions

BEHAVIORAL

No Results Yet

NCT04090619 | ACTIVE_NOT_RECRUITING

192 participants

Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers

Study Type:: OBSERVATIONAL
Last Updated:: 2026-08-06
Start Date:: 2021-06-22
Completion:: 2027-12-31

Conditions

Advanced Malignant Solid Neoplasm
Caregiver
Metastatic Malignant Solid Neoplasm
Recurrent Leukemia
Recurrent Lymphoma
Recurrent Malignant Solid Neoplasm
Recurrent Plasma Cell Myeloma

Interventions

OTHER

No Results Yet

NCT04089358 | ACTIVE_NOT_RECRUITING | PHASE3

387 participants

Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2020-12-07
Completion:: 2025-12-31

Conditions

Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm

Interventions

OTHER
DEVICE
BEHAVIORAL

No Results Yet

NCT04077307 | RECRUITING | PHASE1

50 participants

A Study in Leukemia Patients With Karonudib

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-12-03
Completion:: 2027-04-30

Conditions

Leukemia

Interventions

DRUG

No Results Yet

NCT04061603 | COMPLETED | NA

215 participants

iCLAS™ for Persistent Atrial Fibrillation

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-12-09
Completion:: 2023-08-30

Conditions

Persistent Atrial Fibrillation

Interventions

DEVICE

Results Available

NCT04040049 | TERMINATED | PHASE1/PHASE2

3 participants

A Fabry Disease Gene Therapy Study

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2019-07-08
Completion:: 2023-05-02

Conditions

Fabry Disease
Lysosomal Storage Diseases

Interventions

GENETIC

Results Available

NCT04025918 | COMPLETED | PHASE2/PHASE3

216 participants

Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section

Study Type:: INTERVENTIONAL
Last Updated:: 2026-08-06
Start Date:: 2011-10-31
Completion:: 2012-07-31

Conditions

Hypotension

Interventions

DEVICE
DRUG

No Results Yet