Clinical Trials

NCT04729387 | TERMINATED | PHASE3

358 participants

Alpelisib Plus Olaparib in Platinum-resistant/Refractory, High-grade Serous Ovarian Cancer, With no Germline BRCA Mutation Detected

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-07-22

Completion:

2023-04-21

Conditions

• Ovarian Cancer

Interventions

• DRUG

Results Available

NCT04722835 | RECRUITING

40 participants

Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2021-03-01

Completion:

2030-12-31

Conditions

• Copd
• Smoking
• Tobacco Use

Interventions

• PROCEDURE

No Results Yet

NCT04722172 | ACTIVE_NOT_RECRUITING | PHASE2

55 participants

A Study on Limiting Treatment Time With Acalabrutinib Combined With Obinutuzumab in People With CLL or SLL

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-05-21

Completion:

2027-02-28

Conditions

• Chronic Lymphocytic Leukemia
• Small Lymphocytic Lymphoma

Interventions

• DRUG

No Results Yet

NCT04707651 | ACTIVE_NOT_RECRUITING | NA

20 participants

Formula Diet Treatment for NASH Patients.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-01-18

Completion:

2027-12-31

Conditions

• Steatohepatitis, Nonalcoholic

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT04701671 | ACTIVE_NOT_RECRUITING

180 participants

Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2020-12-10

Completion:

2028-05-09

Conditions

• Pediatric Obesity
• Binge-Eating Disorder

Interventions

• BEHAVIORAL

No Results Yet

NCT04690348 | ACTIVE_NOT_RECRUITING | PHASE2

103 participants

Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-12-24

Completion:

2026-12-31

Conditions

• Recurrent Brain Metastases

Interventions

• PROCEDURE
• RADIATION

No Results Yet

NCT04686084 | COMPLETED | NA

26 participants

Dual Energy Cone-Beam Computed Tomography (DE-CBCT) Assessment of Jaw Bone Density

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-03-26

Completion:

2021-11-29

Conditions

• Dental Diseases

Interventions

• DEVICE

Results Available

NCT04669743 | ACTIVE_NOT_RECRUITING | NA

72 participants

Innate Immunity in Ozone-induced Airway Inflammation in COPD

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2016-04-07

Completion:

2030-12-31

Conditions

• Pulmonary Disease, Chronic Obstructive
• Airway Disease
• COPD Exacerbation
• Pollution; Exposure
• Pollution Related Respiratory Disorder

Interventions

• OTHER

No Results Yet

NCT04664322 | COMPLETED

16 participants

High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2016-02-22

Completion:

2018-02-13

Conditions

• Acute Respiratory Failure With Hypoxia

Interventions

• DEVICE

No Results Yet

NCT04660214 | COMPLETED | NA

85 participants

Minimally Invasive Endoscopic Treatment of Zenker's Diverticulum Comparing LigaSureTM vs SB-Knife.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-06-28

Completion:

2026-05-05

Conditions

• Zenker Diverticulum
• Minimally Invasive Surgical Procedures
• Endoscopy

Interventions

• DEVICE

No Results Yet

NCT04650399 | COMPLETED | PHASE3

754 participants

A Multicenter Study to Evaluate Safety and Immunogenicity of a Live-attenuated Chikungunya Vaccine in Adolescents

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2022-02-14

Completion:

2023-03-14

Conditions

• Chikungunya

Interventions

• BIOLOGICAL

Results Available

NCT04638725 | RECRUITING

9000 participants

Identification of Genetic Determinants for Treatment Resistance/Sensitivity and/or Toxicity in Adjuvant Setting for HER2 Positive Breast Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2021-12-15

Completion:

2033-12-15

Conditions

• HER2-positive Breast Cancer

Interventions

• OTHER

No Results Yet

NCT04630431 | TERMINATED | NA

590 participants

Understanding Challenges, Behavioral Patterns, and Preferences Toward Participation in Clinical Trials in Minority Patient Populations: Development of a Personalized Clinical Trial Educational Platform to Increase Participation in Clinical Trials Among Underserved Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2019-10-15

Completion:

2022-04-12

Conditions

• Hematopoietic and Lymphoid Cell Neoplasm
• Malignant Solid Neoplasm

Interventions

• OTHER
• BEHAVIORAL

No Results Yet

NCT04621435 | RECRUITING | PHASE1

191 participants

Imaging of Solid Tumors Using FAP-2286

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-12-14

Completion:

2026-12-31

Conditions

• Solid Tumors, Adult
• Metastatic Cancer

Interventions

• DRUG
• PROCEDURE

No Results Yet

NCT04573478 | ACTIVE_NOT_RECRUITING | PHASE3

404 participants

Atrasentan in Patients With IgA Nephropathy

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-12-11

Completion:

2028-04-14

Conditions

• IgA Nephropathy
• Immunoglobulin A Nephropathy

Interventions

• DRUG

No Results Yet

NCT04573023 | ACTIVE_NOT_RECRUITING | PHASE3

86 participants

A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2022-02-14

Completion:

2027-10-31

Conditions

• Mucopolysaccharidosis II

Interventions

• DRUG

No Results Yet

NCT04566393 | AVAILABLE

Expanded Access to Ulixertinib (BVD-523) in Patients With Advanced MAPK Pathway-Altered Malignancies

Study Type:

EXPANDED_ACCESS

Last Updated:

2026-06-04

Conditions

• Pancreatic Cancer
• Small Bowel Cancer
• Colorectal Cancer
• Melanoma
• Non Small Cell Lung Cancer
• Thyroid Cancer
• Bladder Cancer
• Head and Neck Cancer
• Gastric Cancer
• Esophageal Cancer
• Cholangiocarcinoma
• Ovarian Cancer
• Hepatocellular Carcinoma
• Glioblastoma
• MAPK Gene Mutation
• KRAS Activating Mutation
• BRAF Gene Mutation
• NRAS Gene Mutation
• HRAS Gene Mutation
• MEK Mutation
• ERK Mutation

Interventions

• DRUG

No Results Yet

NCT04547777 | RECRUITING | PHASE1

90 participants

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-07-09

Completion:

2027-06-30

Conditions

• Glioma, Malignant

Interventions

• DRUG

No Results Yet

NCT04527926 | COMPLETED | NA

1022 participants

STEPuP: Prenatal Provider Education and Training to Improve Medication-assisted Treatment Use During Pregnancy

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-09-30

Completion:

2026-04-30

Conditions

• Opioid-use Disorder
• Pregnancy Related

Interventions

• BEHAVIORAL

No Results Yet

NCT04522791 | COMPLETED | NA

113 participants

Breathing, Relaxation, Attention Training, & Health in Older Adults (BREATHE)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-08-18

Completion:

2026-02-19

Conditions

• Mild Cognitive Impairment
• Healthy Aging

Interventions

• BEHAVIORAL

No Results Yet

NCT04516369 | COMPLETED | PHASE3

4 participants

Study of Efficacy and Safety of Voretigene Neparvovec in Japanese Patients With Biallelic RPE65 Mutation-associated Retinal Dystrophy

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-11-24

Completion:

2022-04-05

Conditions

• Biallelic RPE65 Mutation-associated Retinal Dystrophy

Interventions

• GENETIC

No Results Yet

NCT04502030 | COMPLETED | PHASE3

247 participants

Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-10-05

Completion:

2025-09-19

Conditions

• Chronic Lymphocytic Leukemia
• Hypogammaglobulinemia

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT04468659 | ACTIVE_NOT_RECRUITING | PHASE3

1400 participants

AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-07-14

Completion:

2028-12-21

Conditions

• Preclinical Alzheimer's Disease
• Early Preclinical Alzheimer's Disease

Interventions

• DRUG

No Results Yet

NCT04458259 | TERMINATED | PHASE1

88 participants

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-09-24

Completion:

2024-11-15

Conditions

• Neoplasm Metastasis

Interventions

• DRUG

No Results Yet

NCT04457895 | RECRUITING | NA

108 participants

Evaluation of the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-02-11

Completion:

2028-08-31

Conditions

• Breast Cancer

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT04446442 | RECRUITING | NA

60 participants

Cerebellar tDCS in Children With Autism Spectrum Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2019-06-04

Completion:

2027-12-31

Conditions

• Autism Spectrum Disorder

Interventions

• DEVICE

No Results Yet

NCT04417595 | COMPLETED | PHASE2

237 participants

Omega-3 Fatty Acids for Smoking Cessation in Pregnancy

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-11-10

Completion:

2024-11-30

Conditions

• Preterm Labor
• Tobacco Use Disorder

Interventions

• DRUG

Results Available

NCT04410146 | COMPLETED | NA

319 participants

The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma (STEM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-11-01

Completion:

2024-05-23

Conditions

• Subdural Hematoma, Chronic

Interventions

• DEVICE
• PROCEDURE
• OTHER

Results Available

NCT04406675 | COMPLETED | NA

58 participants

Social Cognition in Patients With Amyotrophic Lateral Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-09-21

Completion:

2026-05-29

Conditions

• Social Cognition

Interventions

• OTHER

No Results Yet

NCT04394637 | ACTIVE_NOT_RECRUITING

110 participants

Ultra High Resolution CT to Assess Role of Intramyocardial Fat and Delayed Enhancement in Ventricular Arrhythmogenesis

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2021-03-04

Completion:

2028-05-31

Conditions

• Ventricular Arrhythmias

No Results Yet

NCT04380350 | COMPLETED

150 participants

Trenza Embolization Device for Intrasaccular Aneurysm Treatment

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2020-12-17

Completion:

2026-02-12

Conditions

• Aneurysm
• Intracranial Aneurysm

No Results Yet

NCT04339036 | RECRUITING | PHASE2

70 participants

CapTemY90 for Grade 2/3 NET Liver Metastases

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2021-10-07

Completion:

2028-07-01

Conditions

• Neuroendocrine Tumor Grade 2
• Neuroendocrine Tumors

Interventions

• DRUG
• COMBINATION_PRODUCT

No Results Yet

NCT04300556 | RECRUITING | PHASE1/PHASE2

182 participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FRα)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-08-06

Completion:

2030-08-08

Conditions

• Solid Tumor

Interventions

• DRUG

No Results Yet

NCT04297605 | RECRUITING | PHASE1

60 participants

Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-05-15

Completion:

2027-11-30

Conditions

• Non-small Cell Lung Cancer

Interventions

• DRUG
• OTHER

No Results Yet

NCT04287621 | COMPLETED

718 participants

Registry of Asthma Patients Initiating DUPIXENT®

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2020-03-02

Completion:

2026-04-27

Conditions

• Asthma

Interventions

• DRUG

No Results Yet

NCT04270617 | RECRUITING | NA

200 participants

The Effect of Yoga Practice on Chronic Back Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2019-12-01

Completion:

2028-01-31

Conditions

• Chronic Back Pain

Interventions

• BEHAVIORAL

No Results Yet

NCT04248335 | COMPLETED | PHASE4

76 participants

Effect of Obesity on Proton Pump Inhibitors

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2018-07-03

Completion:

2024-12-31

Conditions

• Pediatric Obesity
• NAFLD
• GERD

Interventions

• DRUG

Results Available

NCT04236726 | RECRUITING

200 participants

Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure

Study Type:

OBSERVATIONAL

Last Updated:

2026-06-04

Start Date:

2019-12-19

Completion:

2026-12-31

Conditions

• Chronic Obstructive Pulmonary Disease
• Respiratory Failure
• Neuromuscular Diseases
• Ventilatory Failure

Interventions

• OTHER

No Results Yet

NCT04189614 | TERMINATED | PHASE1

65 participants

An Efficacy and Safety Study of Cofetuzumab Pelidotin in Participants With PTK7-Expressing, Recurrent Non-Small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2020-02-13

Completion:

2026-05-07

Conditions

• Cancer
• Non-small Cell Lung Cancer (NSCLC)

Interventions

• DRUG

No Results Yet

NCT04180579 | ACTIVE_NOT_RECRUITING | NA

34 participants

Safety of Lower Scalp Cooling Temperature to Prevent Hair Loss From Chemotherapy in Breast Cancer Patients

Study Type:

INTERVENTIONAL

Last Updated:

2026-06-04

Start Date:

2019-11-26

Completion:

2027-05-31

Conditions

• Breast Cancer
• Breast Cancer Stage I
• Breast Cancer Stage II
• Breast Cancer Stage III

Interventions

• DEVICE

No Results Yet