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Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids

NCT04701671 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2025-12-10

No results posted yet for this study

Summary

Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and psychosocial health complications. Although our recently published data suggest that youth with these conditions may have relative deficits in neurocognitive functioning, particularly working memory, understanding of how these processes and their neural correlates are related to change and stability in eating and weight-related outcomes over time is limited, thereby impeding development of targeted, optimally timed interventions. The present study aims to assess prospective associations between general and food-specific executive functioning and underlying neural substrates, and eating and weight outcomes among children at varying levels of risk overweight/obesity and eating disorders, which will help guide research efforts towards the development of effective prevention and intervention strategies.

Conditions

  • Pediatric Obesity
  • Binge-Eating Disorder

Interventions

BEHAVIORAL

Observational (not including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, and a semi-structured interview.

BEHAVIORAL

Observational (including MRI scanning)

Observational data will be obtained through self-report measures, parental report measures, cognitive assessments, fMRI imaging, and a semi-structured interview.

Sponsors & Collaborators

  • Brown University

    collaborator OTHER

  • The Miriam Hospital

    collaborator OTHER

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Andrea B. Goldschmidt, Ph.D. · University of Pittsburgh

Eligibility

Min Age
9 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-10
Primary Completion
2028-05-09
Completion
2028-05-09

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04701671 on ClinicalTrials.gov