Clinical Trials

NCT05093933 | COMPLETED | PHASE3

6106 participants

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-11-02

Completion:

2024-11-20

Conditions

• Chronic Heart Failure With Reduced Ejection Fraction

Interventions

• DRUG

Results Available

NCT05088798 | RECRUITING | PHASE2

100 participants

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-09-10

Completion:

2030-01-01

Conditions

• Hyperinsulinism

Interventions

• DRUG

No Results Yet

NCT05071352 | COMPLETED | PHASE3

60 participants

Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-10-01

Completion:

2023-03-01

Conditions

• Analgesia
• Critical Illness
• Mechanical Ventilation
• Sedation

Interventions

• DRUG

No Results Yet

NCT05069259 | TERMINATED

18 participants

Generate Real World Data On Tofacitinib Induction Therapy and Changes In Clinical and Patient Reported Outcomes.

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2022-03-28

Completion:

2024-04-30

Conditions

• Ulcerative Colitis

Interventions

• OTHER

Results Available

NCT05047536 | TERMINATED | PHASE1

61 participants

KZR-261 in Subjects With Advanced Solid Malignancies

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-09-30

Completion:

2025-01-17

Conditions

• Advanced/Metastatic Solid Tumor

Interventions

• DRUG

Results Available

NCT05036616 | COMPLETED | NA

80 participants

Separation Versus Integrated Approach in Combining ECMO With CRRT

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-04-01

Completion:

2025-03-10

Conditions

• AKI

Interventions

• DEVICE

No Results Yet

NCT04996082 | COMPLETED

26 participants

Skin Fibrosis Analysis by Raman Spectroscopy in Systemic Sclerosis

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-04-08

Completion:

2023-07-21

Conditions

• Validation of Raman Spectroscopy Usefulness in Systemic Sclerosis

No Results Yet

NCT04983654 | COMPLETED | NA

70 participants

Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2022-02-09

Completion:

2023-10-03

Conditions

• Ulcer
• Anemia
• Sickle Cell Disease

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04962477 | COMPLETED

48 participants

Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2022-03-02

Completion:

2023-09-27

Conditions

• Pregnancy Related
• Innate Inflammatory Response

Interventions

• OTHER

No Results Yet

NCT04947865 | ACTIVE_NOT_RECRUITING | NA

60 participants

Reflex Excitability in Post-stroke Stiff-Knee Gait

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-06-11

Completion:

2025-06-11

Conditions

• Stroke
• Chronic Stroke
• Gait, Hemiplegic
• Gait, Spastic
• Gait Disorder, Sensorimotor
• Gait Disorders, Neurologic
• Walking, Difficulty

Interventions

• OTHER
• DEVICE

No Results Yet

NCT04913038 | COMPLETED

50 participants

Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-06-29

Completion:

2023-11-22

Conditions

• Pain
• Pediatric ALL

No Results Yet

NCT04841746 | COMPLETED | NA

22 participants

Efficacy of FES Cycling After a Severe Form of COVID-19

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-06-02

Completion:

2024-10-02

Conditions

• Covid19
• Ventilators, Mechanical
• Respiratory Distress Syndrome

Interventions

• BEHAVIORAL

No Results Yet

NCT04831138 | TERMINATED | NA

6 participants

Non-Contrast Perfusion Using Arterial Spin Labeled MR Imaging for Assessment of Therapy Response in Metastatic Renal Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-03-24

Completion:

2023-04-04

Conditions

• Renal Cell Carcinoma

Interventions

• OTHER

Results Available

NCT04817449 | COMPLETED

160 participants

Spectroscopy in Ovarian Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-06-28

Completion:

2023-10-01

Conditions

• Ovarian Cancer
• Ovarian Neoplasms
• Ovary Cyst
• Ovary Disease

No Results Yet

NCT04783701 | RECRUITING

360 participants

Coronary CT Angio Evaluating Graft Patency in ACS Patients Treated With DAPT or Single ASA After CABG (CoCAP)

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-05-17

Completion:

2026-02-01

Conditions

• Acute Coronary Syndrome
• Coronary Bypass Stenosis

No Results Yet

NCT04783506 | COMPLETED

225 participants

Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-04-28

Completion:

2025-06-15

Conditions

• Suicide and Depression

Interventions

• OTHER

No Results Yet

NCT04783233 | WITHDRAWN

0 participants

Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-01-14

Completion:

2021-11-03

Conditions

• Tympanoplasty Surgery

Interventions

• BIOLOGICAL

No Results Yet

NCT04782180 | COMPLETED | PHASE4

90 participants

PrEP at a Syringe Services Program

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2022-02-01

Completion:

2024-11-11

Conditions

• Hiv
• Substance Use Disorders

Interventions

• DRUG
• BEHAVIORAL

Results Available

NCT04768309 | COMPLETED | NA

20 participants

Impact of Intestinal Microbiota on Uremic Toxins Productions

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-06-04

Completion:

2021-07-13

Conditions

• CKD
• Uremia

Interventions

• OTHER

No Results Yet

NCT04741269 | COMPLETED

98 participants

Asymmetric Lack of Knee Flexion as a Symptom of DLM in Children

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2020-09-01

Completion:

2020-11-01

Conditions

• Highlights a New Clinical Sign Which Point Out a Meniscus Posterior Luxation Because of a MCA-type DLM

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04691960 | ACTIVE_NOT_RECRUITING | PHASE2

18 participants

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2016-08-31

Completion:

2026-06-30

Conditions

• Glioblastoma

Interventions

• OTHER
• DRUG

No Results Yet

NCT04691297 | ACTIVE_NOT_RECRUITING | NA

153 participants

Digitally Enhanced Smoking Cessation for High Risk Smokers

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-02-01

Completion:

2023-02-01

Conditions

• Smoking
• Smoking Cessation
• Lung Cancer Screening
• Smoking, Tobacco
• Smoking Behaviors

Interventions

• OTHER

No Results Yet

NCT04625478 | COMPLETED

50 participants

Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2020-12-01

Completion:

2021-09-20

Conditions

• Bone and Joint Infection
• Staphylococcus

Interventions

• OTHER

No Results Yet

NCT04585503 | COMPLETED | NA

20 participants

Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-01-01

Completion:

2023-04-07

Conditions

• Brain Lesion
• Head Trauma
• Subarachnoid Hemorrhage

Interventions

• DEVICE

No Results Yet

NCT04579848 | ACTIVE_NOT_RECRUITING | PHASE4

163 participants

Methotrexate in Erosive Inflammatory Hand Osteoarthritis

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-08-12

Completion:

2026-12-31

Conditions

• Hand Osteoarthritis
• Erosive Osteoarthritis

Interventions

• DRUG

No Results Yet

NCT04550104 | RECRUITING | PHASE1

200 participants

A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-03-17

Completion:

2026-03-31

Conditions

• Non Small Cell Lung Cancer

Interventions

• RADIATION
• DRUG

No Results Yet

NCT04517279 | COMPLETED | NA

113 participants

Peer Approaches to Substances in Early Psychosis Programs: A Pilot Study of a Peer-Led Intervention

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2023-08-22

Completion:

2025-07-25

Conditions

• Psychotic Disorders
• Substance Use

Interventions

• BEHAVIORAL

No Results Yet

NCT04495296 | RECRUITING | PHASE1/PHASE2

320 participants

A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-08-13

Completion:

2026-06-25

Conditions

• Advanced Cancer

Interventions

• DRUG

No Results Yet

NCT04464707 | COMPLETED | PHASE3

292 participants

A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-09-24

Completion:

2024-11-29

Conditions

• Migraine

Interventions

• DRUG

Results Available

NCT04447118 | COMPLETED | PHASE3

151 participants

Phase 3 Study of Pyrotinib Versus Docetaxel in Patients With Advanced Non-squamous NSCLC Harboring a HER2 Exon 20 Mutation Who Failed Platinum Based Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-09-11

Completion:

2023-06-02

Conditions

• Non-squamous NSCLC
• HER2 Exon 20 Mutation

Interventions

• DRUG

No Results Yet

NCT04439552 | RECRUITING

60 participants

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2021-10-04

Completion:

2027-08-31

Conditions

• Pain, Postoperative
• Pain, Chronic
• Pain, Acute
• Surgical Injury
• Surgical Wound
• Cornea Injury
• Cornea
• Keratoconus

No Results Yet

NCT04435054 | COMPLETED | NA

1000 participants

Screening for NAFLD-related Advanced Fibrosis in High Risk Population in Diabetology.

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-10-28

Completion:

2023-10-28

Conditions

• Non-Alcoholic Fatty Liver Disease

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04411602 | WITHDRAWN | PHASE1

0 participants

Intermediate IND Severe Illness COVID-19 CP

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-04-07

Completion:

2021-04-07

Conditions

• Severe Acute Respiratory Syndrome
• COVID

Interventions

• DRUG

No Results Yet

NCT04379921 | COMPLETED | NA

255 participants

Improving Spine Surgical Care With Real-Time Objective Patient Tracking Using the Apple Watch

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-09-01

Completion:

2024-11-30

Conditions

• Spine Disease
• Spine Degeneration
• Spinal Stenosis
• Surgery
• Spine Fusion

Interventions

• DEVICE

Results Available

NCT04361656 | WITHDRAWN

0 participants

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2020-05-01

Completion:

2021-02-04

Conditions

• Colonoscopy Preparation

Interventions

• DRUG

No Results Yet

NCT04281056 | RECRUITING | NA

40 participants

Impact of Tooth Loss and Denture on Oral Senses and Food Preferences

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2022-03-16

Completion:

2027-04-30

Conditions

• Tooth-loss

Interventions

• PROCEDURE

No Results Yet

NCT04275973 | COMPLETED | NA

20 participants

Evaluating Mobility Interventions in the Real World

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-09-03

Completion:

2024-08-01

Conditions

• Lower Limb Amputation
• Drop Foot

Interventions

• DEVICE

Results Available

NCT04244604 | COMPLETED | NA

71 participants

Vascular Effects of Acute Sodium (VEAS) Study

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2021-05-03

Completion:

2025-12-15

Conditions

• Sodium Excess
• Racial Disparities
• Blood Pressure
• Cardiovascular Risk Factor

Interventions

• OTHER

No Results Yet

NCT04242394 | COMPLETED

1019 participants

If Chronic Gallbladder Diseases Increase the Incidence of PEC

Study Type:

OBSERVATIONAL

Last Updated:

2025-12-19

Start Date:

2020-02-14

Completion:

2024-11-16

Conditions

• Cholecystitis

Interventions

• PROCEDURE

No Results Yet

NCT04204408 | COMPLETED | PHASE2

275 participants

A Research Study Investigating Mim8 in People With Haemophilia A

Study Type:

INTERVENTIONAL

Last Updated:

2025-12-19

Start Date:

2020-01-10

Completion:

2023-10-06

Conditions

• Healthy Volunteers
• Haemophilia A With or Without Inhibitors

Interventions

• DRUG

No Results Yet