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Reflex Excitability in Post-stroke Stiff-Knee Gait

NCT04947865 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-12-19

No results posted yet for this study

Summary

The purpose of this study is to examine the reflex excitability of the rectus femoris in individuals with and without post-stroke Stiff-Knee gait. We use electrical stimulation of the peripheral nerve innervating the rectus femoris for a well-controlled reflex stimulus. We are investigating whether reflex excitability of the rectus femoris correlates with gait kinematics.

Conditions

  • Stroke
  • Chronic Stroke
  • Gait, Hemiplegic
  • Gait, Spastic
  • Gait Disorder, Sensorimotor
  • Gait Disorders, Neurologic
  • Walking, Difficulty

Interventions

OTHER

Peripheral nerve stimulation

Electrical stimulation of peripheral nerves to measure resulting gait kinematics and surface muscle activity

DEVICE

Commercial knee brace

Knee brace used to limit knee mobility in healthy individuals to imitate stroke survivors and measure resulting gait kinematics and surface muscle activity.

Sponsors & Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    collaborator NIH

  • MetroHealth Medical Center

    lead OTHER

Principal Investigators

  • James S Sulzer · Case Western Reserve University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-11
Primary Completion
2025-06-11
Completion
2026-06-11
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04947865 on ClinicalTrials.gov