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Methotrexate in Erosive Inflammatory Hand Osteoarthritis

NCT04579848 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 163

Last updated 2025-12-19

No results posted yet for this study

Summary

A placebo-controlled randomized controlled trial exploring the effect of methotrexate on pain, function and structural outcomes in erosive inflammatory hand osteoarthritis.

Conditions

  • Hand Osteoarthritis
  • Erosive Osteoarthritis

Interventions

DRUG

Methotrexate Tablets

Methotrexate 2.5mg oral tablet.

DRUG

Placebo

Placebo capsule

DRUG

Folic Acid 1 MG

Folic acid

Sponsors & Collaborators

  • Oslo University Hospital

    collaborator OTHER

  • Diakonhjemmet Hospital

    lead OTHER

Principal Investigators

  • Tore K Kvien, MD, PhD · Professor Em.

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-12
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Norway

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04579848 on ClinicalTrials.gov