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Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

NCT04625478 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-12-19

No results posted yet for this study

Summary

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI.

The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Conditions

  • Bone and Joint Infection
  • Staphylococcus

Interventions

OTHER

Patients having had an osteo-articular infection with Stahylococcus

Immunostaining targeting staphylococci and components will be performed on tissue samples collected from patients with osteo-articular infection

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2021-09-20
Completion
2021-12-20

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04625478 on ClinicalTrials.gov