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VO2max and Substrate Crossover Point

NCT07799662 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-09-02

No results posted yet for this study

Summary

This study aims to investigate the relationship between maximal oxygen uptake (VO2max) and the substrate crossover point during incremental exercise. A total of 20 physical education students are recruited to complete a maximal incremental treadmill test using the standard Bruce protocol. Indirect calorimetry is utilized to assess oxygen uptake (VO2), carbon dioxide production (VCO2), and energy substrate utilization patterns. The substrate crossover point is operationally defined at a respiratory exchange ratio (RER) threshold of 0.85, indicating the metabolic transition toward predominant carbohydrate oxidation. The primary objective is to evaluate how variations in aerobic capacity influence the timing, oxygen uptake, and heart rate (HR) responses at this metabolic transition threshold.

Conditions

  • Cardiorespiratory Fitness
  • Substrate Metabolism During Exercise
  • Metabolic Flexibility
  • Maximal Oxygen Uptake

Interventions

BEHAVIORAL

Incremental Graded Exercise Test (Bruce Protocol)

Participants perform a maximal treadmill exercise test following the standardized Bruce Protocol. The test begins with a warm-up, followed by progressive 3-minute stages with continuous increases in speed and incline until voluntary exhaustion. Indirect calorimetry is used continuously via breath-by-breath gas analysis to measure VO2VCO2, and RER for substrate crossover determination.

Sponsors & Collaborators

  • Celil Kaçoğlu

    lead OTHER

Principal Investigators

  • celil kaçoğlu, Ph.D. · Eskişehir Teknik Üniversitesi

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2026-06-30
Completion
2026-07-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07799662 on ClinicalTrials.gov