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Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.

NCT07790796 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-08-27

No results posted yet for this study

Summary

The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.

Methods (Participants, Interventions, and Outcomes)

Study Setting:

This randomized clinical trial will include 36 patients, equally allocated into three groups (12 patients each). Participants will be recruited from the Outpatient Clinic of the Endodontic Department, Faculty of Oral and Dental Medicine, Future University in Egypt. All treatments will be performed by a postgraduate master's degree candidate using a Ritter dental unit (Germany) and Sirona digital intraoral radiography (Nanopix, size 2).

Eligibility Criteria:

Eligible participants will be 18-40 years old with necrotic pulp and symptomatic apical periodontitis in restorable mandibular first molars (Type III mesial and distal canals) and willing to participate. Exclusion criteria include pregnancy, systemic diseases, recent use of analgesics or antibiotics, bruxism or clenching, severe traumatic malocclusion, and teeth with periapical radiolucency, root resorption, pulp stones/calcifications, or previous endodontic treatment.

Conditions

  • Pulp Necrosis
  • Postoperative Pain

Interventions

DRUG

Root canal treatment with intracanal medication by calcium hydroxide for one week.

Following cleaning and shaping of the root canal, calcium hydroxide paste will be used as an intracanal medicament for one week to reduce bacterial load before the final root canal

DRUG

Root canal treatment with intracanal medication by cocoa husk for one week

Root canal treatment with intracanal medication by cocoa husk for one week

DRUG

Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.

Following cleaning and shaping, no intracanal medicament will be used. The root canal will be obturated according to the study protocol.

Sponsors & Collaborators

  • Future University in Egypt

    lead OTHER

Principal Investigators

  • fatouh · future university

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-06
Primary Completion
2027-01-06
Completion
2027-01-06

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07790796 on ClinicalTrials.gov