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Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

NCT05666089 · Status: UNKNOWN · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-12-27

No results posted yet for this study

Summary

To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on:

* Intensity of postoperative pain.
* Bacterial load reduction.
* levels of MMP -9 in Periapical Fluids.

Conditions

  • Intracanal Medication
  • N-acetylcystine
  • Calcium Hydroxide
  • Mediators

Interventions

DRUG

N-acetyl cysteine

intracanal medication of NAC with concentration 1 gm/ml in the form of a paste

DRUG

Calcium hydroxide

intracanal medication of calcium hydroxide paste (metapaste)

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2024-02-01
Completion
2024-03-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05666089 on ClinicalTrials.gov