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Multi-Strain Probiotic Supplementation, Salivary Immunity, and Upper Respiratory Symptoms in Trained Athletes

NCT07782983 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-08-24

No results posted yet for this study

Summary

This completed external pilot study assessed the feasibility of conducting a randomised, double-blind, placebo-controlled trial of four-week multi-strain probiotic supplementation in trained athletes. Participants were allocated to receive either one probiotic capsule containing 20 billion colony-forming units or a matched rice-flour placebo capsule daily for 28 days. Feasibility measures included recruitment, retention, supplementation adherence and completion of daily monitoring records. Preliminary biological and symptom outcomes included salivary secretory immunoglobulin A and upper respiratory symptom burden. The findings were intended to inform the design of a future definitive randomised controlled trial and were not intended to provide a definitive assessment of efficacy.

Conditions

  • Upper Respiratory Symptoms
  • Mucosal Immunity

Interventions

DIETARY_SUPPLEMENT

Multi-Strain Probiotic

One oral capsule was taken daily for 28 days. Each capsule provided 20 billion colony-forming units and contained Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium lactis Bl-04, Bifidobacterium lactis Bi-07, and Bifidobacterium bifidum Bb-02

DIETARY_SUPPLEMENT

Rice Flour Placebo

One visually matched oral capsule containing rice flour and no live microorganisms was taken daily for 28 days.

Sponsors & Collaborators

  • University of Ulster

    lead OTHER

Principal Investigators

  • Andrea McNeilly, PhD · Ulster University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-13
Primary Completion
2025-12-19
Completion
2025-12-19

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07782983 on ClinicalTrials.gov