Antiviral Activity of Oral Probiotics

Summary

The aim of this study is to test saliva samples obtained from healthy human participants for anti-viral activity after they have consumed S. salivarius probiotic in a powder format.

Conditions

• Lower Respiratory Tract Infection
• Upper Respiratory Tract Infection

Interventions

DIETARY_SUPPLEMENT

Streptococcus salivarius K12 Powder 1 Billion colony forming units /g)

Probiotic Streptococcus salivarius K12 products are commercially available in traditional formats such as lozenges for local delivery in the oral cavity to provide oral health benefits. In this study, a powder formulation will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.

DIETARY_SUPPLEMENT

Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included

In this study, a powder formulation containing Streptococcus salivarius K12 and a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.

DIETARY_SUPPLEMENT

Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)

In this study, a powder formulation will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.

DIETARY_SUPPLEMENT

Streptococcus salivarius M18 Powder (1 Billion colony forming units /g) with a prebiotic included

In this study, a powder formulation containing S. salivarius M18 and a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.

Sponsors & Collaborators

• John Hale

  lead INDUSTRY

Principal Investigators

• John D Hale, PhD · Blis Technologies Ltd, Dunedin, New Zealand

• John R Tagg, PhD · Blis Technologies Ltd, Dunedin, New Zealand

• Liam Harold, PhD · Blis Technologies Ltd, Dunedin, New Zealand

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-05-23

Primary Completion

2022-06-23

Completion

2022-08-15

Countries

• New Zealand

Study Locations